Quantcast
Channel: DR ANTHONY MELVIN CRASTO Ph.D – All About Drugs
Viewing all articles
Browse latest Browse all 823

Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J

$
0
0

Thumbnail image of graphical abstract

Acting on actin: The mechanism of action of amphidinolide X and amphidinolide J, two relatively small cytotoxic macrolides, has been elucidated. They do not target microtubules and intermediate filaments. The effects observed in A549 and PtK2 cells and the in vitro interaction with actin monomer (G-actin) indicate that these macrolides behave as actin-assembly inhibitors.

Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J

  1. Chiara Trigili1,
  2. Benet Pera1,
  3. Dr. Marion Barbazanges2,
  4. Prof. Dr. Janine Cossy2,
  5. Dr. Christophe Meyer2,
  6. Dr. Oriol Pineda3,
  7. Dr. Carles Rodríguez-Escrich3,
  8. Prof. Fèlix Urpí3,
  9. Prof. Dr. Jaume Vilarrasa3,*,
  10. Dr. J. Fernando Díaz1,* and
  11. Dr. Isabel Barasoain1,*

DOI: 10.1002/cbic.201100042

Author Information

  1. 1Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid (Spain), Fax: (+34) 915360432
  2. 2Laboratoire de Chimie Organique, ESPCI, CNRS, 75231 Paris 05 (France)
  3. 3Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain)

*Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain)

Trigili, C., Pera, B., Barbazanges, M., Cossy, J., Meyer, C., Pineda, O., Rodríguez-Escrich, C., Urpí, F., Vilarrasa, J., Díaz, J. F. and Barasoain, I. (2011), Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J. ChemBioChem, 12: 1027–1030. doi: 10.1002/cbic.201100042

////////////Cytotoxic Macrolides,  Amphidinolide X and J

Share


Viewing all articles
Browse latest Browse all 823

Trending Articles