Acting on actin: The mechanism of action of amphidinolide X and amphidinolide J, two relatively small cytotoxic macrolides, has been elucidated. They do not target microtubules and intermediate filaments. The effects observed in A549 and PtK2 cells and the in vitro interaction with actin monomer (G-actin) indicate that these macrolides behave as actin-assembly inhibitors.
Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J
DOI: 10.1002/cbic.201100042
Author Information
Email: Prof. Dr. Jaume Vilarrasa (jvilarrasa@ub.edu), Dr. J. Fernando Díaz (i.barasoain@cib.csic.es), Dr. Isabel Barasoain (fer@cib.csic.es)
*Departament de Química Orgànica, Facultat de Química, Universitat de Barcelona, Diagonal 647, 08028 Barcelona (Spain)
Trigili, C., Pera, B., Barbazanges, M., Cossy, J., Meyer, C., Pineda, O., Rodríguez-Escrich, C., Urpí, F., Vilarrasa, J., Díaz, J. F. and Barasoain, I. (2011), Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J. ChemBioChem, 12: 1027–1030. doi: 10.1002/cbic.201100042
Vol. 12, Issue 9, 1293, Version of Record online: 9 JUN 2011
http://onlinelibrary.wiley.com/doi/10.1002/cbic.201100042/abstract
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