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Channel: DR ANTHONY MELVIN CRASTO Ph.D – All About Drugs
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Copolymeric Micelles for Anticancer Drug Delivery

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Copolymeric Micelles for Anticancer Drug Delivery

Photo-activatable micelles with a platinum prodrug backbone

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http://www.chemistryviews.org/details/news/9914881/Copolymeric_Micelles_for_Anticancer_Drug_Delivery.html?elq_mid=12498&elq_cid=1558306

Abstract

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A simultaneously photo-cleavable and activatable prodrug-backboned block copolymer (BCP) micelle strategy is demonstrated. Without light treatment, the micelles stay silent and inactivated, being biocompatible to normal tissues. Concurrent chain cleavage of BCP micelles and the activation of Pt(IV) prodrug could be temporally and spatially triggered by UV or even visible light for precise anticancer drug delivery.

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