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Anthony Melvin Crasto gets International award for Outstanding contribution...
Share: Conferred CMO Asia award 2018 singapore Shobha and Aishal crasto collect my International award for Excellence in Pharma by CMO ASIA 31st July 2018 | at an award function in Le Méridien...
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Development and Scale-Up of a Continuous Reaction for Production of an Active...
Share: Flow reactor equipment that was used in the piloting of the aldol flow chemistry. (a) The tube-in-shell heat exchangers were used to control stream temperature upstream and downstream of the...
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Ethyl 4, 6-dichloro-1H-indole-2-carboxylate
Share:Ethyl 4, 6-dichloro-1H-indole-2-carboxylate ethyl 4,6-dichloro-1H-indole-2-carboxylate (1a) (2.70 kg, 99.5%). Mp 187–188 °C; HRMS (ESI) m/z [M – H]− calcd for C11H8NO2Cl2 255.9927, found...
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Process Development of Febuxostat Using Palladium- and Copper-Catalyzed C–H...
Share: There is significant interest in the development of process routes for active pharmaceutical ingredients using C–H arylation methodology. An efficient and practical synthetic route for...
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Crystallization
Share: Crystallization is the (natural or artificial) process by which a solid forms, where the atoms or molecules are highly organized into a structure known as a crystal. Some of the ways by which...
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1-(4-Cyanophenyl)piperazine
Share: 1-(4-Cyanophenyl)piperazine 1-(4-Cyanophenyl)piperazine (1a).1 Isolated as a mixture of mono (1a) and di (3) arylated products ~9:1. Conversion: quantitative. Peaks attributed to 1a: 1H NMR (400...
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Development of an SNAr Reaction: A Practical and Scalable Strategy To...
Share: A simple and operationally practical method to sequester and remove fluoride generated through the SNAr reaction between amines and aryl fluorides is reported. Calcium propionate acts as an...
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A call to (green) arms: a rallying cry for green chemistry and engineering...
Share: A call to (green) arms: a rallying cry for green chemistry and engineering for CO2 capture, utilisation and storage Julien Leclaire*a and David J. Heldebrant*b Author affiliations...
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3-fluoro-4- morpholinoaniline
Share: 3-fluoro-4- morpholinoaniline 1H NMR (400MHz, CDCl3) 6.82 (m, 1H, ArH), 6.43 (m, 2H, 2xArH), 3.87 (m, 4H, 2xCH2O), 3.58 (brs, 2H, NH2), 2.99 (m, 4H, 2xCH2N). 13C NMR (100MHz, CDCl3) 156.9 (d...
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4-(2-fluoro-4-nitrophenyl)morpholine
Share: 4-(2-fluoro-4-nitrophenyl)morpholine 1H NMR (400MHz, CDCl3) 8.03 (ddd J=1.0, 2.6 and 9.0Hz, 1H, ArH), 7.94 (dd J=2.6 and 13.1Hz, 1H, ArH), 6.94 (t J=8.7Hz, 1H, ArH), 3.90 (t J=4.7Hz, 4H,...
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2-amino-4-bromo-5-fluorobenzoic acid
Share: 2-amino-4-bromo-5-fluorobenzoic acid as a white to off-white crystalline solid 1H NMR (400 MHz, DMSO-d6) δ 7.62 (d, J=9.6 Hz, 1H), 7.21-6.5 (m, 3H), 3.8- 3.3 (br s, 1H). 13C NMR (100 MHz,...
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Quetiapine
Share: Quetiapine 1H NMR (400 MHz, CD3OD): δ = 3.18-3.27 (m, 4H), 3.35-3.44 (m, 3H), 3.56-3.58 (m, 3H), 3.67-3.69 (m, 3H), 3.76 (t, J = 5.2 Hz, 2H), 4.32 (s, 1H), 6.88 (td, J = 7.4 Hz, 1.2 Hz, 1H),...
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Kalyan Kumar Pasunooti, 5-Methylisoxazole-3-carboxamide-Directed...
Share: Palladium-catalyzed acetoxylation of the primary γ-C(sp3)–H bonds in the amino acids Val, Thr, and Ile was achieved using a newly discovered 5-methylisoxazole-3-carboxamide directing group. The...
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API, Impurities and Regulatory aspects
Share: The impurities in pharmaceuticals are unwanted chemicals that remain with the active pharmaceutical ingredients (APIs) or develop during formulation or upon aging of both API and formulation....
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Carbanio – a digital B2B platform to buy and sell Chemicals in India
Share:Hello All I have an exciting news which I want to share today. Couple of days ago, I was browsing on the internet to see if we can buy ready stock of Chemicals online, especially from Indian...
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Latest artificial glucose-binding receptor is best yet
Share: It’s a receptor that binds glucose strongly and with the highest selectivity yet. Could help with #diabetes treatment: http://ow.ly/EPzn30mDYjf Read all at...
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Use of Lipase Catalytic Resolution in the Preparation of Ethyl...
Share: Here we describe an efficient and cost-effective chemoenzymatic synthesis of the β-lactamase inhibitor avibactam starting from commercially available ethyl 5-hydroxypicolinate hydrochloride....
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Anthony Crasto conferred ABPnews award for “Outstanding contribution to...
Share: Conferred prestigious award at event ABP News Presents Healthcare Leadership Awards 26th November, 2018 at Taj Lands End, Mumbai India Dedicated to Shobha Crasto Aishal crasto Lionel crasto...
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Article 0
Share: Sodium aluminate is presented as a highly active heterogeneous catalyst that is able to convert a range of alcohols into the corresponding unsymmetrical carbonate esters by reaction with...
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(1S,4R)-2-(4-Methoxybenzoyl)bicyclo[2.2.2]octa-2,5-diene
Share: (1S,4R)-2-(4-Methoxybenzoyl)bicyclo[2.2.2]octa-2,5-diene (3a) Yellow liquid (25.2 mg, 95% yield): 1H NMR (300 MHz, CDCl3) 1.39 (s, 4H, alkyl), 3.77-3.80 (m, 1H, alkyl), 3.85 (s, 3H, OMe),...
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