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NEW PATENT WO2015188782, METHOD FOR PREPARING SOFOSBUVIR
Share:SOFOSBUVIR NEW PATENT WO2015188782, (WO2015188782) METHOD FOR PREPARING SOFOSBUVIR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD [CN/CN]; No. 8 Julong North Rd., Xinpu District Lianyungang,...
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MONITORING FLUORINATIONS……Selective direct fluorination for the synthesis of...
Share: . Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom...
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Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
Share: Recently, application of the flow technologies for the preparation of fine chemicals, such as natural products or Active Pharmaceutical Ingredients (APIs), has become very popular, especially...
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Twelve Principles for Drug Optimization
Share: Twelve Principles for Drug Optimization 1. Increasing Potency In the analogue class of the histamine H2-receptor antagonists (cimetidine, nizatidine, ranitidine, roxatidine, and famotidine),...
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Current Practices of Process Validation for Drug Substances and Intermediates
Share: Process validation includes laboratory optimization, pilot-plant introduction, and process implementation on manufacturing scale, as well as monitoring batches after implementation and...
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Facts, Growth, and Opportunities in Industrial Biotechnology
Share: The revolution in synthetic biology has enabled innovative manufacture of biofuels and the development of biological processes for the manufacture of bulk and fine chemicals. This short review...
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WO 2016018024, DAPAGLIFLOZIN, HANMI FINE CHEMICAL CO., LTD, New patent
Share: (S) – propylene glycol and water, 1: 1 crystalline complex PATENT WO2016018024, CRYSTALLINE COMPOSITE COMPRISING DAPAGLIFLOZIN AND METHOD FOR PREPARING SAME HANMI FINE CHEMICAL CO., LTD....
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VASICINE, (peganine)
Share:. Vasicine (peganine) is a quinazoline alkaloid. It is the active compound of Justicia adhatoda, after which the chemical is named. Vasicine has been compared to theophylline both in vitro and in...
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BENFOTIAMINE
Share: Benfotiamine S-[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-phosphonooxypent-2-en-3-yl] benzenecarbothioate Benphothiamine; Betivina; Biotamin; Neurostop; Nitanevril;22457-89-2...
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Biocon’s Rosuvastatin Calcium tablets get EU approval to treat hyperlipidemia
Share: Biocon’s Rosuvastatin Calcium tablets get EU approval to treat hyperlipidemia Indian biopharmaceutical company Biocon has received approval from the European Commission for its Rosuvastatin...
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ONL 1204 a small molecule peptide for Treatment of retinal detachment
Share: OR ONL 1204 CAS 1349038-53-4...
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AVORALSTAT
Share: Avoralstat, BCX4161, CAS 918407-35-9 UNII: UX17773O15 513.5513, C28-H27-N5-O5 2-Pyridinecarboxylic acid,...
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Application of On-Line NIR for Process Control during the Manufacture of...
Share: The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of...
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Catalyst-free thiolation of indoles with sulfonyl hydrazides for the...
Share: Catalyst-free thiolation of indoles with sulfonyl hydrazides for the synthesis of 3-sulfenylindoles in water Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00313C, Communication Yu Yang,...
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Pd(II) pincer type complex catalyzed tandem C-H and N-H activation of...
Share: Pd(II) pincer type complex catalyzed tandem C-H and N-H activation of acetanilide in aqueous media: a concise access to functionalized carbazoles in a single step Green Chem., 2016, Advance...
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Crystallization of Artemisinin from Chromatography Fractions of Artemisia...
Share: Crystallization is an inevitable step in the purification of artemisinin either from the plantArtemisia annua or from reaction mixtures of semisynthetically produced artemisinin. Rational design...
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Efficient formation of nitriles in the vapor-phase catalytic dehydration of...
Share: Efficient formation of nitriles in the vapor-phase catalytic dehydration of aldoximes Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00384B, Paper Daolai Sun, Eisyun Kitamura, Yasuhiro...
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Nanopalladium-catalyzed conjugate reduction of Michael acceptors –...
Share: Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow Green Chem., 2016, Advance Article DOI: 10.1039/C5GC02920A, Communication Anuja Nagendiran, Henrik...
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ITI 214
Share: ITI 214 IC200214; ITI-214 (6aR,9aS)-2-(4-(6-fluoropyridin-2-yl)benzyl)-5-methyl-3-(phenylamino)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4-(2H)-one phosphate...
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