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Breaking the symmetry of dibenzoxazines: a paradigm to tailor the design of...
Share: Green Chem., 2016, Advance Article DOI: 10.1039/C5GC03102H, Paper L. Puchot, P. Verge, T. Fouquet, C. Vancaeyzeele, F. Vidal, Y. Habibi Asymmetric di-benzoxazine monomers from naturally...
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An Improved Process for the Preparation of Tenofovir Disoproxil Fumarate
Share: Tenofovir Disoproxil Fumarate PAPER The current three-step manufacturing route for the preparation of tenofovir disoproxil fumarate (1) was assessed and optimized leading to a higher...
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New FDA Guidance on Completeness Assessements for Type II API Drug Master Files
Share: Since 1st October 2012, special regulations have been applying to the US Type II Drug Master Files. This year in February, the FDA published a new Guidance for Industry. Read here what the DMF...
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Second Revision of USP Chapter Injections and Implanted Drug Products...
Share: After the revision of the General Chapter on quality testing of sterile medicinal products in the US American Pharmacopoeia had already been announced last year in the USP 38-NF 33, the USP is...
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ECA releases Version 18 of GMP Guideline Manager
Share: How to access ten thousand pages of GMP Guidelines from FDA, EMA, ICH, PIC/S, ICH, WHO and many other organisations worldwide? You can print them or purchase hundreds of booklets. Or,...
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Already 13 EMA GMP Non-compliance Reports in 2016 published
Share: EudraGMDP is the central database for GMP and GDP compliance. Inspections which have been performed by any of the EU member state inspectorates are published in the database. Please get the...
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Trioxacarcin A
Share: Trioxacarcin A, DC-45A CAS No. 81552-36-5 Molecular FormulaC42H52O20 Average mass876.850 Da...
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Trichloroacetic Acid Removal by a Reductive Spherical Cellulose Adsorbent
Share: Chemical Research in Chinese Universities Vol.32 No.1 February 2016 2016 Vol. 32 (1): 0-0 [Abstract] ( 20 ) [HTML 1KB] [PDF 2198KB] ( 11 ) A novel spherical cellulose adsorbent with amide and...
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Cycloaddition of epoxides and CO2 catalyzed by bisimidazole-functionalized...
Share: Cycloaddition of epoxides and CO2 catalyzed by bisimidazole-functionalized porphyrin cobalt(III) complexes Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00370B, Paper Xu Jiang,...
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A pot-economical and diastereoselective synthesis involving catalyst-free...
Share: Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00497K, Communication Xiaofeng Zhang, Sanjun Zhi, Wei Wang, Shuai Liu, Jerry P. Jasinski, Wei Zhang A pot-economical synthesis involving two...
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Phytochemical compounds or their synthetic counterparts? A detailed...
Share: Green Chem., 2016, 18,1807-1818 DOI: 10.1039/C6GC00090H, Paper Elisabetta Zerazion, Roberto Rosa, Erika Ferrari, Paolo Veronesi, Cristina Leonelli, Monica Saladini, Anna Maria Ferrari LCA of...
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FDA approves new treatment for inhalation anthrax, Anthim (obiltoxaximab)...
Share: Anthim (obiltoxaximab) ETI-204 March 21, 2016 Release http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm491470.htm On Friday, March 18, the U.S. Food and Drug Administration approved...
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BRIVARACETAM
Share: BRIVARACETAM, UCB-34714 (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide (2S)-2-[(4R)-2-Oxo-4-propyl-1-pyrrolidinyl]butanamide 1-Pyrrolidineacetamide, α-ethyl-2-oxo-4-propyl-, (αS,4R)- CAS...
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Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody...
Share: The number of antibiotic-resistant bacterial infections has increased dramatically over the past decade. To combat these pathogens, novel antimicrobial strategies must be explored and developed....
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Palladium-Catalyzed Aerobic Oxidative Coupling of o-Xylene in Flow: A Safe...
Share: Herein, the first continuous cross-dehydrogenative homocoupling of an unactivated arene using oxygen as sole oxidant is reported. Employing microreactor technology which enables the use of...
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PF-06747775 (Pfizer) Third generation covalent EGFR inhibitors
Share: PF-06747775 (Pfizer) PF06747775; PF06747775; PF 06747775; PF6747775; PF 6747775; PF6747775. PFE-X775...
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罗西替尼 роцилетиниб روسيليتينيب Rociletinib, CO-1686. Third generation covalent...
Share: Rociletinib (CO-1686) AVL-301,CNX-419 Celgene (Originator) , Clovis Oncology N-(3-{[2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-...
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EGF 816 , Nazartinib
Share: EGF 816, Nazartinib EGF-816; EGFRmut-TKI EGF816 Novartis Ag innovator (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide...
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Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic...
Share: We present a series of oxadiazolothiazinones, selective inotropic agents on isolated cardiac tissues, devoid of chronotropy and vasorelaxant activity. Functional and binding data for the...
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Tianagliflozin, IND filed by Tianjin Institute of Pharmaceutical research
Share: Tianagliflozin, taigeliejing, 6-deoxydapagliflozin Molecular Formula: C21H25ClO5 Molecular Weight: 392.8732 g/mol IND Filing…Tianjin Institute of Pharmaceutical research Tianjin Institute Of...
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