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Processes for Constructing Homogeneous Antibody Drug Conjugates
Share: Antibody drug conjugates (ADCs) are synthesized by conjugating a cytotoxic drug or “payload” to a monoclonal antibody. The payloads are conjugated using amino or sulfhydryl specific linkers that...
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Sun Pharma and Merck & Co. Inc. Enter into Licensing Agreement for Tildrakizumab
Share: Tildrakizumab (MK-3222) Company Merck & Co. Inc. Description Anti-IL-23 antibody Molecular Target Interleukin-23 (IL-23) Mechanism of Action Antibody Therapeutic Modality Biologic: Antibody...
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A New Antibiotic...
Share: (E)-3-(3-Carboxyphenyl)-2-(4-ethynylstyryl)quinazolin-4(3H)-one (E)-3-(2-(4-Cyanostyryl)-4-Oxoquinazolin-3(4h)-Yl)benzoic Acid; 1624273-22-8 CAS NA SALT 1624273-21-7 CAS INNOVATORS University...
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Development of a Safe and Robust Process for the Large-Scale Preparation of a...
Share: The large-scale synthesis of ethyl 4-bromocyclohex-3-enecarboxyalate, using a mild brominating reagent derived from triphenyl phosphite and bromine, is reported. The development and comparison...
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Potential of Homogeneous Pd Catalyst Separation by Ceramic Membranes....
Share: Successful chemical production of molecules while simultaneously reducing the environmental impact of the process relies not only on more efficient reactions but also on developments in reactor...
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Continuous Flow Magnesiation of Functionalized Heterocycles and Acrylates...
Share: Knochel’s group in Munich have recently disclosed how a variety of functionalised heterocycles and sensitive acrylates can be rapidly magnesiated and subsequently quenched with an...
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CADROFLOXACIN
Share: Cadrofloxacin , CS 940 3-Quinolinecarboxylic acid, 1-cyclopropyl-8-(difluoromethoxy)-6-fluoro-1,4-dihydro-7-[(3S)-3-methyl-1-piperazinyl]-4-oxo-, hydrochloride (1:1) UNII-1YOQ7J9ACY;...
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Nolatrexed Dihydrochloride
Share: Nolatrexed NDA Filed in china A thymidylate synthase inhibitor potentially for the treatment of hepatocellular carcinoma and nasopharyngeal cancer. AG-337 CAS No. 147149-76-6 (free) free form...
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Arbaclofen
Share: Arbaclofen placarbil (3R)-3-(4-chlorophenyl)-4-[[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino]butanoic acid NDA filed A GABA (B) receptor agonist potentially for the treatment of...
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Ixorine, a New Cyclopeptide Alkaloid from the Branches of Ixora brevifolia
Share: Figure 2 Selected key HMBC (1H 13C) and NOESY (1H 1H) correlations for ixorine (1). Figure 1 Structures of compounds 1–4 isolated from the branches of I. brevifolia. Ixorine (1) HRESIMS m/z,...
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Lupin to co-market Novartis’ asthma drug in India
Share: Lupin to co-market Novartis’ asthma drug in India BS B2B Bureau | Mumbai April 12, 2016 Last Updated at 10:27 IST Novartis Healthcare will continue to market Sequadra...
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Multibiphenyl A, New biphenyls from Garcinia multiflora.
Share: Figure 2 Selected HMBC (H→C) and 1H-1H correlation spectroscopy (COSY) (–) correlations of 1. Compound 1 was obtained as a pale yellow gum. The molecular formula was determined to be C20H22O6...
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Buthionine Sulphoximine
Share: Buthionine Sulphoximine NDA Filed in china A gamma-glutamylcysteine synthetase inhibitor potentially for the treatment of solid tumors. NSC-326231; BSO CAS No. 5072-26-4 BUTHIONINE SULFOXIMINE;...
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EMA’s new Draft Guideline on the Sterilisation of Medicinal Products, APIs,...
Share: For medicinal products administrated in sterile form, the process to reduce the microbial level is a critical manufacturing step with regard to quality. The EMA has recently published the draft...
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USP publishes draft of a new general chapter for plastic components used in...
Share: In the Pharmacopoeial Forum (PF) 42(3) (May-June 2016) the USP General Chapters – Packaging and Distribution Expert Committee proposes a new general chapter <661.3> Plastic Components...
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APIs from Legitimate and Reliable Sources
Share: APIs from Legitimate and Reliable Sources 1. Introduction Counterfeit and sub-standard APIs are increasingly present. Not only are they a fact of non-compliance but also they form a serious and...
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Illegal Drugs in Dietary Supplements
Share: Illegal Drugs in Dietary Supplements Forbidden stimulant oxilofrine found in various dietary supplements sold in the USA Read more...
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Printing with Collagen
Share: Printing with Collagen Addition of collagen to hydrogels in 3D printing improves stem cell differentiation in osteogenesis Read more...
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Dihydrobenzofuran Neolignans
Share: Figure 1 Structures of dihydrobenzofuran neolignans 2a and 2b. Scheme 1 (i) Ag2O, (CH3)2CO:C6H6 3:5, r.t., 20 h (2a: 36% yield; 2b: 43% yield). Figure 3 Main nuclear Overhauser effect (NOE)...
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Palladium- and Nickel-Catalyzed Amination of Aryl Fluorosulfonates
Share: Examples of the palladium- and nickel-catalyzed amination of aryl fluorosulfonates with aromatic and alkyl amines are described. Aniline is coupled to a diverse series of aryl fluorosulfonates...
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