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EMA issues new Guideline on “Chemistry of Active Substances”
Share: The new EMA “Guideline on the chemistry of active substances” represents the current state of the art in regulatory practice and fits into the context of the ICH Guidelines Q8-11. Find out what...
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Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous...
Share: The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which...
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(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol , Furofuranol
Share: CAS : 156928-09-5 Molecular Formula: C6H10O3 Molecular Weight: 130.144 Furo[2,3-b]furan-3-ol, hexahydro-, [3R-(3α,3aβ,6aβ)]- (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol...
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One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive...
Share: One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases Green Chem., 2017, Advance Article DOI: 10.1039/C6GC03023H, Communication P. Matzel, M....
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Reflections on Chirality in the Pharmaceutical Industry: Past, Present and...
Share: Christopher Welch New Technologies, Postdoc Program, Science Lead, Analytical Chemistry at Merck christopher_welch@merck.com Reflections on Chirality in the Pharmaceutical Industry: Past,...
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GMP’s for Early Stage Development of new Drug substances and products
Share: GMP’s for Early Stage Development of New Drug substances and products The question of how Good Manufacturing Practice (GMP) guidelines should be applied during early stages of development...
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Highly Selective Phosgene-Free Carbamoylation of Aniline by Dimethyl...
Share: Over the last 20 years organic carbamates have found numerous applications in pesticides, fungicides, herbicides, dyes, pharmaceuticals, cosmetics, and as protecting groups and intermediates for...
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4-(2-Hydroxyethyl)-1,3-dihydro-2H-indol-2-one
Share: 13C NMR (DMSO-d6, 100 MHz): δ = 35.2, 36.8, 61.5, 107.4, 122.5, 125.4, 127.8, 136.1, 143.8, 176.9; 1H NMR 1H NMR (DMSO-d6, 400 MHz): δ = 2.64 (t, J = 6.8 Hz, 2H), 3.44 (s, 2H), 3.59 (q, J =...
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A deeper shade of green: inspiring sustainable drug manufacturing
Share: Green and sustainable drug manufacturing go hand in hand with forward-looking visions seeking to balance the long-term sustainability of business, society, and the environment. However, a lack...
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Overcoming barriers to green chemistry in the pharmaceutical industry – the...
Share: Scheme 1. Pfizer’s Commercial Synthesis of sildenafil citrate (Viagra™) “Green chemistry” refers to the promotion of safe, sustainable, and waste-minimizing chemical processes. The...
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Towards automation of chemical process route selection based on data mining
Share: A methodology for chemical routes development and evaluation on the basis of data-mining is presented. A section of the Reaxys database was converted into a network, which was used to plan...
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A catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and...
Share: We have reported herein a catalyst-free 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines and 3-nitroindoles by which a series of five-ring-fused tetrahydroisoquinolines featuring an...
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Methyl (Z)-11-[(3-Hydroxy)propylidene]-6,11-dihydrobenz[b,e]oxepin-2-acetate
Share: E/Z WO2014147647 White solid; Ή NMR (200 MHz, CDC13 + CC14): δ 2.38-2.49 ( m,0.8H, E- Form), 2.63-2.73 ( m,1.2H, Z-Form), 3.53 (s, 2H), 3.68 (s, 3H), 3.75 (m, 0.8H, E-Form), 3.81 (t, J=6.3 Hz,...
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Crystallization and relaxation dynamics of amorphous loratadine under...
Share: CrystEngComm, 2017, 19,335-345 DOI: 10.1039/C6CE01645F, Paper Ruimiao Chang, Qiang Fu, Yong Li, Mingchan Wang, Wei Du, Chun Chang, Aiguo Zeng In this paper, four amorphous samples of loratadine...
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[3 + 2] Dipolar Cycloadditions in Flow Reactors
Share: FLOW CHEMISTRY ILLUSTRATION Flow chemistry is also known as continuous flow or plug flow chemistry. It involves a chemical reaction run in a continuous flow stream. The process offers potential...
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Amtolmetin guacil
Share: Amtolmetin guacil, ST-679, MED-15, Eufans CAS 87344-06-7 UNII: 323A00CRO9, Molecular Formula, C24-H24-N2-O5, Molecular Weight, 420.463, 2-Methoxyphenyl...
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Drug Patent expiry in 2017
Share: “ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This article is a compilation for educational purposes only. P.S. : The views...
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An Improved Process for Pioglitazone and Its Pharmaceutically Acceptable Salt
Share: Improved synthetic approach: route A (feasibility) and B (after optimization) Rakeshwar Bandichhor Ph.D. FRSC, CChem, SSWB,BB,MB Director at Dr. Reddy’s Laboratories, Vice-Chair, ACS-India...
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FDA publishes Final Guideline on GMP for Combination Products
Share: In the beginning of 2015 the FDA has published a draft guideline about GMP for Combination Products. Now the final version has been published. What are the differences between the draft and...
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EMA publishes Q&A on Health Based Exposure Limits – Does the 1/1000 dose...
Share: In 2014 the European Medicines Agency (EMA) issued the Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in...
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